Paternal Lymphocyte Immunization (PLI) / Lymphocyte Immunotherapy (LIT)
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Paternal Lymphocyte Immunization (PLI) / Lymphocyte Immunotherapy (LIT)
What is Paternal Lymphocyte Immunization (PLI)?
PLI is a specialized immunotherapy treatment where white blood cells (lymphocytes) are collected from the male partner (or a donor), processed, and then injected into the woman’s arm. This exposure helps her immune system develop blocking antibodies that may prevent it from rejecting the embryo, which contains foreign genetic material from the father.Endometrial Rejuvenation involves using Platelet-Rich Plasma (PRP) therapy, derived from your own blood, to promote growth and regeneration of the endometrium. The growth factors in PRP are injected into the uterine cavity to stimulate cellular repair and improve thickness and blood flow
Our PLI Treatment Process Includes:
- Comprehensive Immune Testing: We first conduct tests to identify potential immune factors that may be contributing to recurrent loss or implantation failure.
- Patient Selection: Determining if you are a candidate for PLI based on your history and test results.
- Blood Draw & Processing: A blood sample is taken from the male partner. The lymphocytes are isolated and prepared in a specialized lab.
- Immunization: The prepared lymphocytes are injected intradermally (into the skin) on the woman's forearm, similar to a TB test.
- Treatment Timing: The immunization is typically performed before conception or before an embryo transfer cycle, and may be repeated to maintain immune tolerance.
Common Questions, About PLI
Q: Is PLI a common treatment?
A: It is a specialized and somewhat controversial treatment, not offered by all clinics. It is typically considered after extensive testing has ruled out other more common causes of miscarriage.
Q: What is the evidence for its success? A: Studies show mixed results, but some demonstrate improved live birth rates in women with unexplained recurrent miscarriage. We will discuss the evidence and its applicability to your case in detail.
Q: Are there any side effects?
A: The risks are low. The most common side effect is redness, swelling, or itching at the injection site. There is a very small risk of infection or an allergic reaction.
Q: What are my next steps?
A: Your next step is to schedule a detailed consultation with Dr. Jyoti Bandi to review your history and see if immune testing and PLI are appropriate for you. Call us at 083103 09167 or schedule online at www.drjyotibandi.in.
Why Choose Us for PLI in Bangalore?
- Addressing Complex Issues: We offer this treatment for selected patients where all other causes of recurrent loss have been ruled out, and immune dysfunction is suspected.
- Specialized Protocol: We follow strict, internationally recognized protocols for preparing and administering the immunotherapy.
- Integrated Care: This treatment is part of a larger, comprehensive plan that may include other fertility treatments like IVF.
- A Path Forward: For couples who have faced unexplained recurrent loss, PLI can offer a new avenue of hope and a potential solution.
Doctor Profile – Dr. Jyoti Bandi
- Name: Dr. Jyoti Bandi
- Specialization: Reproductive Medicine & Fertility Specialist ( Gynecologist and Fertility Specialist)
- Qualifications: MBBS, MS (OBG), DMAS (Germany), DRM (Germany), MCG (AAA, Dubai)
- Experience: 13+ Years Experience Overall
- Focus: Helping couples achieve their dream of parenthood with compassion and advanced medical care.